5 6 Moreover, different dominant hands lead to different health outcomes for example, different times to mortality were found in populations with a different dominant hand. 3ĭespite growing epidemiological evidence regarding the relationship between HGS and mental illness, studies using HGS or other objective physical performance measures to explore strength loss as an indicator of MDD and other common mental health conditions have yielded inconsistent results. 4 Owing to the strength of the evidence in this area, HGS is now considered an easily administered and clinically useful index of cognitive decline across the lifespan. Assessing HGS asymmetry may provide insights into HGS, as one study has verified that handgrip asymmetry would hasten mortality. 3 Handgrip strength (HGS) is quickly assessed and provides an objective measure of muscular fitness, emerging as an important biomarker of overall health and disease status. Recent years witnessed the increasing recognition of the importance of objective physical fitness tests as indicators of physical, mental and cognitive outcomes in the general population. 2 However, preventing MDD has been challenging, with few established protective factors, particularly modifiable targets for prevention. 1 These cognitive deficits impair social and occupational functioning, contributing to the personal, social and economic burden associated with mood disorders. Major depressive disorder (MDD) is a common psychiatric condition that represents a leading cause of disability worldwide and is associated with deficits in cognition, including executive function and memory.
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